超顺磁性氧化铁纳米粒作为磁共振成像造影剂的研究概况

饶跃峰，李慧婷，，曹国洪，卢晓阳*

中国药学杂志 ›› 2014, Vol. 49 ›› Issue (15) : 1291-1294.

PDF(703 KB)
中国药学杂志
PDF(703 KB)
中国药学杂志 ›› 2014, Vol. 49 ›› Issue (15) : 1291-1294. DOI: 10.11669/cpj.2014.15.004
综述

超顺磁性氧化铁纳米粒作为磁共振成像造影剂的研究概况

  • 饶跃峰1，李慧婷1，2，曹国洪1，卢晓阳1*
作者信息 +

The Overview of Superparamagnetic Iron Oxide Nanoparticles (SPION) as MRI Contrast Agents

  • RAO Yue-feng1, LI Hui-ting1,2, CAO Guo-hong1, LU Xiao-yang1*
Author information +
文章历史 +

摘要

目的 综述超顺磁性氧化铁纳米粒(superparamagnetic iron oxide nanoparticles，SPION)作为磁共振成像造影剂的国内外研究进展。方法 在Pubmed和Google资源上检索近30年来国内外相关资料，阐述磁共振成像造影剂原理和分类，介绍超顺磁性氧化铁纳米粒的结构、特性及制备方法，对新一代超顺磁性氧化铁纳米粒造影剂在磁共振成像技术及其在生物医学中应用进行总结和评论。结果 超顺磁性氧化铁纳米粒造影剂已成为磁共振成像中重要的临床诊断药物，在肝脏、淋巴系统和胰腺、中枢神经系统及肾脏疾病的诊断和治疗方面已取得系列成果。结论 超顺磁性氧化铁纳米粒在医学基础研究和临床应用上具有广阔的应用前景，开发具有靶向性、高效、安全的超顺磁性氧化铁纳米粒造影是目前该领域研究主要方向之一。

Abstract

To review the latest development of the superparamagnetic iron oxide nanoparticles(SPION) as contrast agent for magnetic resonance imagine(MRI). METHODS Pubmed and Google database were researched for the pertinent studies conducted in the recent thirty years. The mechanism and category, as well as the properties and fabrication of SPION were reviewed. The applications of this novel SPION contrast agent were summarized and commented. RESULTS MRI has become an important and non-substitutable means for clinical medical examination and clinical diagnosis. The SPION has drawn particular interest as a sonderful MRI contrast agent for their enhanced relaxation rate, flexible modification, multifunctional targeting, and non-toxic degradation manner. It has been successfully applied in the diagnosis and treatment for the diseases of liver, lymphatic and pancreatic system, central nervous system and and soon. CONCLUSION As novel contrast agent, SPION shows a broad application prospect in basic biomedical research and clinical medicine. Currently, the main trend of the related research is to develop targeting, well-biocompatible SPION and to modify its biochemical characters.

关键词

超顺磁氧化铁性纳米粒 / 造影剂 / 磁共振成像 / 靶向性

Key words

superparamagnetic iron oxide nanoparticle(SPION) / contrast agent / magnetic resonance imaging(MRI) / targeting

引用本文

EndNote

Ris (Procite)

Bibtex

导出引用
饶跃峰，李慧婷，，曹国洪，卢晓阳*. 超顺磁性氧化铁纳米粒作为磁共振成像造影剂的研究概况[J]. 中国药学杂志, 2014, 49(15): 1291-1294 https://doi.org/10.11669/cpj.2014.15.004
RAO Yue-feng, LI Hui-ting,, CAO Guo-hong, LU Xiao-yang*. The Overview of Superparamagnetic Iron Oxide Nanoparticles (SPION) as MRI Contrast Agents[J]. Chinese Pharmaceutical Journal, 2014, 49(15): 1291-1294 https://doi.org/10.11669/cpj.2014.15.004
中图分类号： R943   

参考文献

[1] HUANG S, FENG S M, LI R, et al. Current research progress of contrast agent at home and abroad . Chin Pharm J (中国药学杂志), 2010,45(16): 1213-1217.[2] DING J, ZHAO J H, LI W, et al. The preparation of dextran modified meso-superparamagnetic iron oxide nanoparticles . Chin J Lab Diagn (中国实验诊断学), 2007, 11(1): 102-104.[3] LIN S P, BROWN J J. MR contrast agents: Physical and pharmacologic basics . J Magn Reson Imaging, 2007, 25(5): 884-899.[4] ZHANG W. The progress in the application of MRI target contrast agent in tumor diagnosis . Chongqing Med (重庆医学), 2011, 40(6): 609-611.[5] BELLIN M F. MR contrast agents, the old and the new . Eur J Radiol, 2006, 60(3): 314-323.[6] TANG S D, OU Y Y, WENG M, et al. Pharmacokinetic parameters and main organ distribution of c-erbB2 antisense probe labeled with superparamagnetic iron oxide nanoparticles in vivo. Chin Pharm J (中国药学杂志), 2011, 46(21): 1656-1660.[7] XIAO Y, WU Y J, ZHANG W J, et al. Research progress of magnetic resonance imaging contrast agents . Analytic Chem(分析化学), 2011, 39(5): 757-764.[8] KOBAYASHI S, MATSUI O, GABATA T, et al. Relationship between signal intensity on hepatobiliary phase of gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA)-enhanced MR imaging and prognosis of borderline lesions of hepatocellular carcinoma . Eur J Radiol, 2012, 81(11): 3002-3009.[9] NWE K, BERNARDO M, REGINO C A, et al. Comparison of MRI properties between derivatized DTPA and DOTA gadolinium-dendrimer conjugates .Bioorg Med Chem, 2010, 18(16): 5925-5931. ZUO C S, SEOANE P R, HU J, et al. MR Imaging of the stomach: Potential use for mangafodipir trisodium-a study in swine . Radiology, 2004, 232(1): 160-163. YANG Y D, YU Z Q, PAN W S, et al. Advancement of research about superparamagnetic contrast agents . Prog Modern Biomed(现代生物医学进展), 2007, 7(9): 1387-1390. LU X Y, RAO Y F, LOU Y, et al. Superparamagnetic iron oxide nanoparticles: Key physicochemical properties and biomedical applications . Chin J Mod Appl Pharm (中国现代应用药学), 2013, 30(2): 209-213. MEI W, WANG Z X, XIAO Z W. Principle and application of functional MRI enhanced by superparamagnetic iron oxide contrast agents . Chin J Med Imaging Technol (中国医学影像技术), 2007, 23(12): 1899-1903. JIN X, CHEN Z L, LIU S T, et al. Quality study of SPIO colloid solution . Chin Hosp Pharm J (中国医院药学杂志), 2008, 28(10): 787-790. DI MARCO M, SADUN C, PORT M, et al. Physicochemical characterization of ultrasmall superparamagnetic iron oxide particles (USPIO) for biomedical application as MRI contrast agents . Int J Nanomed, 2007, 2(4): 609-622. JIANG W, ZHOU Y, ZHANG Y, et al. Superparamagnetic Ag@Fe3O4 core-shell nanospheres: Fabrication, characterization and application as reusable nanocatalysts . Dalton Trans, 2012, 41(15): 4594-4601. ZHANG B, CHENG J, GONG X, et al. Facile fabrication of multi-colors high fluorescent/superparamagnetic nanoparticles. J Colloid Interface Sci, 2008, 322(2): 485-490. YANG S, LIU H, HUANG H, et al. Fabrication of superparamagnetic magnetite/poly (styrene-co-12-acryloxy-9-octadecenoic acid) nanocomposite microspheres with controllable structure. J Colloid Interface Sci, 2009, 338(2): 584-590. WOLF G L, BURNETT K R, GOLDSTEIN E J, et al. Contrast agents for magnetic resonance imaging . Magn Reson Annu, 1985,11(5):231-266. WEISSLEDER R, SAINI S, STARK D D, et al. Dual-contrast MR imaging of liver cancer in rats.AJR Am J Roentgenol, 1988, 150(3): 561-566. DAI Y, WU Y K. Research status of superparamagnetic iron oxide MR contrast agent:Marking features,safety and limitation . J Clin Rehab Tissue Engineering Res (中国组织工程研究与临床康复), 2010, 14(3): 513-516. CHEN Z J, YU D X, HOU J L, et al. Advance of liver targeted magnetic resonance imaging molecular contrast agent . Chin J New Drugs Clin Rem (中国新药与临床杂志), 2010, 29(5): 332-335. LOCATELLI E, GIL L, ISRAEL L L, et al. Biocompatible nanocomposite for PET/MRI hybrid imaging . Int J Nanomed, 2012, 7: 6021-6033. DENG L, KE X, HE Z, et al. A MSLN-targeted multifunctional nanoimmunoliposome for MRI and targeting therapy in pancreatic cancer . Int J Nanomed, 2012, 7: 5053-5065. ZHANG Y T, ZHANG J. Contrast agent enhancement in brain tumors. Chin Comput Med Imag (中国医学计算机成像杂志), 2000, 6(4): 263-268. LOGOTHETIS N K. What we can do and what we cannot do with fMRI. Nature, 2008, 453(7197): 869-878. ZHANG B L, ZHANG H Y. Application of superparamagnetic iron oxide nanoparticles as contrast agents in brain magnetic resonance imaging . Chin J Magn Reson Imaging (磁共振成像), 2011, 2(5): 377-383. DRIVER J, BLANKENBURG F, BESTMANN S, et al. Concurrent brain-stimulation and neuroimaging for studies of cognition . Trends Cogn Sci, 2009, 13(7): 319-327. TSUCHIYA K, NITTA N, SONODA A, et al. Evaluation of atherosclerotic lesions using dextran- and mannan-dextran-coated USPIO: MRI analysis and pathological findings . Int J Nanomed, 2012, 7: 2271-2280. SCHMITZ S A, O′REGAN D P, FITZPATRICK J, et al. White matter brain lesions in midlife familial hypercholesterolemic patients at 3-Tesla magnetic resonance imaging . Acta Radiol, 2008, 49(2):184-189. SHEN M, GONG F, PANG P, et al. An MRI-visible non-viral vector for targeted Bcl-2 siRNA delivery to neuroblastoma . Int J Nanomedicine, 2012, 7: 3319-3332. CHEN Y, WANG W, LIAN G, et al. Development of an MRI-visible nonviral vector for siRNA delivery targeting gastric cancer . Int J Nanomedicine, 2012, 7: 359-368. THOREK D L, CHEN A K, CZUPRYNA J, et al. Superparamagnetic iron oxide nanoparticle probes for molecular imaging . Ann Biomed Eng, 2006, 34(1): 23-38.

基金

国家自然科学基金资助项目(81072231)
PDF(703 KB)

77

Accesses

0

Citation

Detail
段落导航
相关文章

/

〈 〉